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A specific chemical and transcription factor combination specifies and expands hematopoietic stem and progenitor cells in zebrafish embryonic cell culture.
Method for Inducing Hematopoietic Stem Cell Specificity
Background
Hematopoietic stem cells (HSCs), found primarily in bone marrow, are crucial for blood cell formation and immune system function. While transplantation of allogeneic and autologous HSCs is common for treating various life-threatening disorders, the procedure carries high risks, primarily...
Published: 3/26/2026
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Updated: 11/4/2025
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Inventor(s): Leonard Zon, Joseph Mandelbaum, Anne Robertson
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Using defined factors to engineer niche endothelial cells for growing and maintaining blood stem cells
Use of engineered niche endothelial cells to grow and maintain blood stem cells
Background
Hematopoietic stem and progenitor cells (HSPCs) are a rare cell population found in bone marrow that are responsible for producing all blood and immune cells. These cells are especially valuable for their ability to regenerate the entire blood system after transplantation...
Published: 3/25/2026
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Updated: 11/4/2025
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Inventor(s): Leonard Zon, Elliott Hagedorn
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Combination Treatment for Melanoma
Combination Treatment for Melanoma
Methods for treating melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and a combination therapy
Technology Overview
Oncogenic BRAF mutations are present in most melanomas and have been implicated in the malignant growth of melanoma cells. Researchers at Boston Children’s Hospital have discovered...
Published: 3/25/2026
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Updated: 1/6/2023
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Inventor(s): Leonard Zon, Richard White
Keywords(s): Melanoma
Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Oncology, Technology Classifications > Disease Area, Technology Classifications > Invention Type
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