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Advancements in Botulinum Neurotoxin Engineering: Enhancing Therapeutic Efficacy and Safety through Novel Receptor-Binding and Protease Domain Modifications
Advancements in Botulinum Neurotoxin Engineering: Enhancing Therapeutic Efficacy and Safety through Novel Receptor-Binding and Protease Domain Modifications
Background
Botulinum neurotoxins (BoNT) are bacterial toxins used in medical and cosmetic applications for their ability to block neurotransmitter release, causing targeted paralysis. While BoNT/A...
Published: 3/26/2026
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Updated: 11/29/2025
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Inventor(s): Min Dong
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics
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Application of novel enterococcus pore-forming toxins
Advancing Treatment for Antibiotic-Resistant Infections with Enterococcus Pore-Forming Toxin Technology
Background
Enterococcus faecalis and Enterococcus faecium have emerged as significant contributors to multidrug-resistant (MDR) infections, posing a substantial threat to public health due to their inherent and acquired resistance to antibiotics....
Published: 3/20/2026
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Updated: 10/6/2025
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Inventor(s): Min Dong, Xiaozhe Xiong, Songhai Tian
Keywords(s):
Category(s): Technology Classifications > Invention Type > Research Tools > Protein (Research Tool), Technology Classifications > Invention Type > Therapeutics > Peptide, Technology Classifications > Disease Area > Infectious Disease
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Targeting Neurogenic Inflammation to Combat Clostridioides difficile Infections
Targeting Neurogenic Inflammation to Combat Clostridioides difficile Infections
Background
Clostridioides difficile infection (CDI) is a prevalent gastrointestinal condition in developed countries, notably causing approximately half a million cases and 29,000 deaths annually in the United States alone. This infection arises from a disruption in the...
Published: 3/30/2026
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Updated: 7/28/2025
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Inventor(s): Meenakshi Rao, Melissa Musser, Min Dong
Keywords(s):
Category(s): Technology Classifications > Disease Area > Gastroenterology, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Peptide
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