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Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Background
Bronchopulmonary dysplasia (BPD) is a chronic lung condition primarily affecting premature infants due to exposure to oxygen or mechanical ventilation impacting their immature lungs. BPD affects...
Published: 3/13/2026
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Updated: 3/13/2026
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Therapeutic Applications of Exosomes/Microvesicles from Bone Marrow Mesenchymal Cells in Pulmonary Disease
Therapeutic Applications of Exosomes/Microvesicles from Bone Marrow Mesenchymal Cells in Pulmonary Disease
Background
Premature infants face a critical risk of developing chronic lung diseases such as bronchopulmonary dysplasia (BPD), impacting about 35-40% of those born before 29 weeks of gestation. BPD alongside pulmonary hypertension (PH) results...
Published: 3/12/2026
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Updated: 3/12/2026
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis, Konstantino Sdrimas
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Invention Type > Therapeutics > Drug Delivery, Technology Classifications > Invention Type > Therapeutics
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Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Background
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants related to oxygen exposure or mechanical ventilation of the developing, immature lungs. BPD occurs approximately...
Published: 3/24/2026
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Updated: 12/20/2024
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Fetal/Newborn Medicine, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Intravenous and topical VEGF accelerates compensatory lung growth
Intravenous and topical VEGF accelerates compensatory lung growth
Background
In hypoplastic lung diseases, the lungs fail to properly develop. Some examples of these disorders are congenital diaphragmatic hernia (CHD), a rare condition that occurs during fetal development in which a hole in the diaphragm allows abdominal organs to move up into the...
Published: 3/30/2026
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Updated: 1/24/2024
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Inventor(s): Mark Puder
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Invention Type > Therapeutics > Protein
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Pediatric Airway Stent to Treat Tracheobronchomalacia
Pediatric Airway Stent to Treat Tracheobronchomalacia
Background
Tracheobronchomalacia (TBM) is a congenital defect of the central airways that has been identified in up to 15% of infants and 30% of young children undergoing bronchoscopic examination for respiratory distress. The condition can arise due to intrinsic weaknesses in the trachea...
Published: 6/26/2025
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Updated: 1/19/2024
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Inventor(s): Pierre Dupont, Aditya Kaza, Karl Price, Zhanyue Zhao, Junhyoung Ha
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Invention Type > Medical Devices > Instruments
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Inhibition of IP6K1 Suppresses Neutrophil-mediated Pulmonary Damage in Bacterial Pneumonia
Inhibition of IP6K1 Suppresses Neutrophil-mediated Pulmonary Damage in Bacterial Pneumonia
A personalized therapeutic approach for treating gram positive and gram negative bacterial infections of the lung
Background
Antibacterial resistance (AMR) to both Gram-positive and Gram-negative bacterial species is a serious global, public-health concern,...
Published: 3/20/2026
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Updated: 3/7/2023
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Inventor(s): Hongbo (Robert) Luo
Keywords(s):
Category(s): Technology Classifications > Disease Area, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Pulmonary
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Real-time Monitoring of Breathing and Heart Function: an Alert System for Medical Emergencies
Real-time Monitoring of Breathing and Heart Function: an Alert System for Medical Emergencies
Effective monitoring and early warning system that can detect an advancing respiratory or cardiac emergency
Background
Many patients suffering from chronic conditions such as asthma and COPD are at risk of experiencing potentially fatal emergencies. These...
Published: 3/20/2026
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Updated: 2/15/2023
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Inventor(s): Benjamin Matthews, Christopher Norve
Keywords(s):
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Medical Devices, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Cardiology, Technology Classifications > Disease Area > Pulmonary
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