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Therapeutic Applications of Exosomes/Microvesicles from Bone Marrow Mesenchymal Cells in Pulmonary Disease
Therapeutic Applications of Exosomes/Microvesicles from Bone Marrow Mesenchymal Cells in Pulmonary Disease
Background
Premature infants face a critical risk of developing chronic lung diseases such as bronchopulmonary dysplasia (BPD), impacting about 35-40% of those born before 29 weeks of gestation. BPD alongside pulmonary hypertension (PH) results...
Published: 3/12/2026
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Updated: 3/12/2026
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis, Konstantino Sdrimas
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Invention Type > Therapeutics > Drug Delivery, Technology Classifications > Invention Type > Therapeutics
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Extracellular vesicles as an antenatal treatment for the prevention of pregnancy loss, preeclampsia and fetal growth restriction.
Innovative Antenatal Therapy: Harnessing Mesenchymal Stem Cell Exosomes for Treating Placental Insufficiency and Preeclampsia
Background
Placental insufficiency and its complications, such as preeclampsia, pose significant challenges in maternal and fetal healthcare. Affecting millions globally, these conditions can lead to long-term neurological,...
Published: 3/23/2026
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Updated: 7/29/2025
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis, Elizabeth Taglauer
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Disease Area > Reproductive Health > Prenatal Care
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Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Background
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants related to oxygen exposure or mechanical ventilation of the developing, immature lungs. BPD occurs approximately...
Published: 3/24/2026
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Updated: 12/20/2024
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Fetal/Newborn Medicine, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Background
Since the thymus is an essential organ for the production and maturation of specific immune T-cells, poor thymus development early in life can lead to multiple diseases related to immunological disorders. These diseases can manifest early, with an increased propensity...
Published: 3/23/2026
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Updated: 7/11/2023
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s): Immunology, Newborn Medicine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Autoimmune
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