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TLR7/8 Ligands for Use in Opioid Vaccines
TLR7/8 Ligands for Use in Opioid Vaccines
Ligands with the potential for preventing fatal overdose of opioid users and protect against or treat Opioid Use Disorder patients
Technology Overview
Building on their work as part of the Precision Vaccines Program, researchers in the Levy lab have developed a method of enhancing immune response to anti-opioid...
Published: 3/24/2026
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Updated: 3/24/2026
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Inventor(s): Ofer Levy, David Dowling, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Lipid Gb3 as an adjuvant for anti-viral vaccination
Lipid Gb3 as adjuvant for anti-viral vaccination
Background
Adjuvants are vaccine components added to enhance the magnitude, breadth, and durability of response.
Selection of appropriate adjuvants requires improved understanding of immune responses to pathogens/antigens by B cells (white blood cells). B cells develop in the bone marrow and are...
Published: 3/23/2026
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Updated: 1/12/2024
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Inventor(s): Florian Winau, Pankaj Sharma
Keywords(s): Adjuvants, Immunology
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Vaccines > Adjuvants
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In situ targeted drug delivery to sites of intravascular heterotypic aggregates in sickle cell disease (SCD) by red blood cells encapsulated with drug candidates.
In situ targeted drug delivery to sites of intravascular heterotypic aggregates in sickle cell disease (SCD) by red blood cells encapsulated with drug candidates
Background
Recent advances highlight potential use of red blood cells (RBCs) as efficient drug delivery systems (DDS) for sickle cell disorders (SCD), either by incorporating the...
Published: 3/20/2026
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Updated: 7/17/2023
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Inventor(s): Leslie Silberstein, Shin-Young Park, Jina Ryu, Min Liu
Keywords(s): Immunology
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Background
Since the thymus is an essential organ for the production and maturation of specific immune T-cells, poor thymus development early in life can lead to multiple diseases related to immunological disorders. These diseases can manifest early, with an increased propensity...
Published: 3/23/2026
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Updated: 7/11/2023
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s): Immunology, Newborn Medicine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Autoimmune
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Novel Bacteriotherapies for the prevention and treatment of Food Allergy
Novel Bacteriotherapies for the prevention and treatment of Food Allergies
Background
Most food allergies are acquired in the first years of life, indicating a critical role for early childhood exposures in disease pathogenesis. Reduced bacterial diversity and an impaired ratio of specific bacteria in infancy have been associated with food sensitization,...
Published: 3/20/2026
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Updated: 7/11/2023
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Inventor(s): Talal Chatila, Azza Abdel-Gadir, Emmanuel Stephen Victor, Rima Rachid, Lynn Bry, Georg Gerber
Keywords(s): Allergy, Common, Food Allergy, Immunology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Microbiome, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology > Allergy
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MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
Background
Though vaccination is one of the greatest accomplishments of modern medicine, there are still challenges to the production of perfectly effective vaccines. These challenges include weakened response by the vaccinated individual’s immune system...
Published: 3/24/2026
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Updated: 5/31/2023
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Inventor(s): Simon van Haren, Ofer Levy, Guzman Sanchez-Schmitz, David Dowling
Keywords(s): Drug Delivery, Immunology, Infectious Disease, Vaccine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Research Tools, Technology Classifications > Invention Type > Research Tools > Assay, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease
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TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine
TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine
The molecule 3M-052 offers effective immunization with one birth dose, representing a new paradigm in early life vaccine development
Technology Overview
Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical...
Published: 3/24/2026
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Updated: 3/6/2023
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Inventor(s): Ofer Levy, David Dowling, Jay Evans, Helene Brazin-Lee, David Burkhart, Alyson Smith
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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STING Agonists as Immunomodulators and Vaccine Adjuvants
STING Agonists as Immunomodulators and Vaccine Adjuvants
STING agonists proven to be effective vaccine adjuvants and immunomodulators in newborns
Background
Infectious diseases are the leading cause of morbidity and mortality in early life and immunization is a key preventive strategy. Vaccine adjuvants can enhance, prolong, and modulate immune responses...
Published: 3/30/2026
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Updated: 3/6/2023
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Inventor(s): Ofer Levy, Carlo Pietrasanta, David Dowling, Francesco Borriello
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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