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TLR7/8 Ligands for Use in Opioid Vaccines
TLR7/8 Ligands for Use in Opioid Vaccines
Ligands with the potential for preventing fatal overdose of opioid users and protect against or treat Opioid Use Disorder patients
Technology Overview
Building on their work as part of the Precision Vaccines Program, researchers in the Levy lab have developed a method of enhancing immune response to anti-opioid...
Published: 3/24/2026
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Updated: 3/24/2026
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Inventor(s): Ofer Levy, David Dowling, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Synthetic genes that rewire natural immune pathways for anti-tumor defense
Synthetic genes that rewire natural immune pathways for anti-tumor defense
Background
Cancer is a malignant tumor resulting from the formation of abnormal cells in the body that can grow in an out-of-control fashion, eventually becoming fatal in the absence of effective, timely treatment. Interferons are a family of proteins that can naturally regulate...
Published: 3/9/2026
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Updated: 6/21/2023
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Inventor(s): Jonathan Kagan, Yunhao Tan
Keywords(s): Cancer, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Background
Blood coagulation is an essential physiological process where the blood changes from a liquid form into a thicker, gel-like form in response to a blood vessel injury thereby preventing excessive blood...
Published: 6/26/2025
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Updated: 6/21/2023
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Inventor(s): Daniel Kohane, Juan Ibla, Upendra Katneni, Chava Kimchi-Sarfaty
Keywords(s): Cardiovascular, Molecules/ Proteins, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Protein
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A novel antibody drug conjugate to treat pancreatic cancer
Novel Antibody Conjugate to Treat Pancreatic Cancer
Background
Pancreatic cancer (PC) represents 7% of all cancer mortalities and has a strikingly poor prognosis with PC patients having a 5-year survival rate of less than 8% despite recently intensified studies of immunotherapy and nanomedicine therapy. The immunosuppressive microenvironment of pancreatic...
Published: 6/26/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Jing Huang, Peng Guo
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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Specialized adeno-associated virus for central nervous system gene therapy
Specialized adeno-associated virus for central nervous system gene therapy
Background
Unlike other cell types in the human body, nerve cells (neurons) have an extremely limited ability to replace themselves through division following damage to the nervous system. Most injuries and diseases of the central nervous system (CNS) involve damage to axons,...
Published: 9/16/2025
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Updated: 6/9/2023
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Inventor(s): Zhigang He, Xue Yao, Zicong Zhang, Benedikt Brommer
Keywords(s): CNS, Gene Therapy, Therapeutic, Trauma
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
Background
Breast cancer is the most common cancer in women. It accounts for 12.5% of all cancers globally and women in the United States have a 1 in 8 chance of developing breast cancer. While the 5-year survival is about 90% for...
Published: 6/30/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Peng Guo, Jing Huang, Jianmin Fang
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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Novel Antibiotic from a Costa Rican Fungus
Novel Antibiotic from a Costa Rican Fungus
Small-molecule antibiotic with activity against commonly drug-resistant species
Background
Antibiotic-resistant microbes have become a global problem, with an estimated 48,000 deaths attributed to resistant microbes in the U.S. and Europe alone. The constant threat of the development of resistance has led...
Published: 9/26/2025
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Updated: 5/5/2023
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Inventor(s): Paula Watnick, Patrick Ymele-Leki, Jon Clardy, Shugeng Cao
Keywords(s): Antibiotic, Research Tool, Small Molecule, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine
TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine
The molecule 3M-052 offers effective immunization with one birth dose, representing a new paradigm in early life vaccine development
Technology Overview
Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical...
Published: 3/24/2026
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Updated: 3/6/2023
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Inventor(s): Ofer Levy, David Dowling, Jay Evans, Helene Brazin-Lee, David Burkhart, Alyson Smith
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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STING Agonists as Immunomodulators and Vaccine Adjuvants
STING Agonists as Immunomodulators and Vaccine Adjuvants
STING agonists proven to be effective vaccine adjuvants and immunomodulators in newborns
Background
Infectious diseases are the leading cause of morbidity and mortality in early life and immunization is a key preventive strategy. Vaccine adjuvants can enhance, prolong, and modulate immune responses...
Published: 3/30/2026
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Updated: 3/6/2023
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Inventor(s): Ofer Levy, Carlo Pietrasanta, David Dowling, Francesco Borriello
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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Heat Shock Machinery as a Druggable Target in Tuberous Sclerosis Complex
Heat Shock Machinery as a Druggable Target in Tuberous Sclerosis Complex
A treatment for Tuberous Sclerosis as well as other neuropsychiatric disorders with altered cilia
Background
Tuberous Sclerosis Complex (TSC) is a neurogenetic disorder that leads to the formation of tumors in many different organs including the brain, eyes, heart, kidney, and...
Published: 6/26/2025
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Updated: 2/14/2023
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Inventor(s): Alessia Di Nardo, Mustafa Sahin
Keywords(s): Rare Disease, Therapeutic, Therapeutics:Novel Molecules:Small molecules
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets
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