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Copper depletion for treatment of cancer in the brain (as a primary or secondary site)
Targeting Copper Metabolism to Improve Cancer Therapy Efficacy
Background
Acute Lymphoblastic Leukemia (ALL), one of the most common childhood cancers, is a type of cancer that originates in the bone marrow and can spread to various parts of the body, including the central nervous system (CNS) through cerebrospinal fluid. This can lead to deadly...
Published: 3/27/2026
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Updated: 12/17/2025
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Inventor(s): Naama Kanarek, Alan Wong
Keywords(s): Cancer
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Novel Targets
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Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Background
Triple-negative (TNBC) and HER2+ breast cancers (BCs) are especially aggressive tumors with the worst prognosis as they are prone to relapse and metastasize post chemo- or targeted therapy. Immunotherapy provides...
Published: 3/9/2026
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Updated: 7/28/2023
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Inventor(s): Judy Lieberman, Ying Zhang
Keywords(s): Cancer, Oncology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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Synthetic genes that rewire natural immune pathways for anti-tumor defense
Synthetic genes that rewire natural immune pathways for anti-tumor defense
Background
Cancer is a malignant tumor resulting from the formation of abnormal cells in the body that can grow in an out-of-control fashion, eventually becoming fatal in the absence of effective, timely treatment. Interferons are a family of proteins that can naturally regulate...
Published: 3/9/2026
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Updated: 6/21/2023
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Inventor(s): Jonathan Kagan, Yunhao Tan
Keywords(s): Cancer, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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Antibody mediated conditioning with immunosuppression to enable allogeneic transplantation
Antibody mediated conditioning with immunosuppression to enable allogeneic transplantation
Background
Hematopoietic (blood-forming) stem cell transplantation (HSCT) is the transplantation of autologous or allogeneic hematopoietic stem cells used to treat patients with cancer and disorders of the blood and immune system. Hematopoietic stem cells are...
Published: 3/2/2026
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Updated: 5/25/2023
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Inventor(s): Derrick Rossi, Agnieszka Czechowicz, Philip Murphy, Zhanzhuo Li
Keywords(s): Allogeneic Transplantation, Autoimmmune, Cancer, CRISPR, Gene Therapy
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Hematology
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Nanoparticles Targeting Gene Editing Systems to Cancer Cells
Nanoparticles Targeting Gene Editing Systems to Cancer Cells
Targeted gene therapy delivery platform for oncology indications with stable nanoparticles and no cytotoxicity
Background
To date, existing gene editing delivery systems involve viral vectors or cationic materials, which carry a high human safety concern. Researchers at Boston Children’s...
Published: 6/30/2025
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Updated: 5/5/2023
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Inventor(s): Marsha Moses, Peng Guo, Jiang Yang, Debra Auguste
Keywords(s): Cancer, Gene Therapy, Oncology, Viral Vector
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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