Search Results - oncology

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Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown

Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown Background Triple-negative (TNBC) and HER2+ breast cancers (BCs) are especially aggressive tumors with the worst prognosis as they are prone to relapse and metastasize post chemo- or targeted therapy. Immunotherapy provides...

Published: 3/9/2026 | Updated: 7/28/2023 | Inventor(s): Judy Lieberman, Ying Zhang

Keywords(s): Cancer, Oncology

Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology

Synthetic genes that rewire natural immune pathways for anti-tumor defense

Synthetic genes that rewire natural immune pathways for anti-tumor defense Background Cancer is a malignant tumor resulting from the formation of abnormal cells in the body that can grow in an out-of-control fashion, eventually becoming fatal in the absence of effective, timely treatment. Interferons are a family of proteins that can naturally regulate...

Published: 3/9/2026 | Updated: 6/21/2023 | Inventor(s): Jonathan Kagan, Yunhao Tan

Keywords(s): Cancer, Oncology, Therapeutic

Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology

A novel antibody drug conjugate to treat pancreatic cancer

Novel Antibody Conjugate to Treat Pancreatic Cancer Background Pancreatic cancer (PC) represents 7% of all cancer mortalities and has a strikingly poor prognosis with PC patients having a 5-year survival rate of less than 8% despite recently intensified studies of immunotherapy and nanomedicine therapy. The immunosuppressive microenvironment of pancreatic...

Published: 6/26/2025 | Updated: 6/9/2023 | Inventor(s): Marsha Moses, Jing Huang, Peng Guo

Keywords(s): Common, Oncology, Therapeutic

A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers

A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers Background Breast cancer is the most common cancer in women. It accounts for 12.5% of all cancers globally and women in the United States have a 1 in 8 chance of developing breast cancer. While the 5-year survival is about 90% for...

Published: 6/30/2025 | Updated: 6/9/2023 | Inventor(s): Marsha Moses, Peng Guo, Jing Huang, Jianmin Fang

Keywords(s): Common, Oncology, Therapeutic

Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Large Molecule

Rapid MRI Acquisition By Image Reconstruction Augmented with Inter-voxel Constraints

Rapid MRI Acquisition By Image Reconstruction Augmented with Inter-voxel Constraints A novel and effective algorithm to reduce the geometry-factor artifacts in parallel magnetic resonance imaging. Background Magnetic resonance imaging (MRI) is one of the most versatile and safest imaging modalities with numerous applications in medicine. One of the...

Published: 3/30/2026 | Updated: 6/7/2023 | Inventor(s): Simon Warfield, Ali Pouryazdanpanah Kermani, Onur Afacan

Keywords(s): Diagnostics, Oncology, Radiology

Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Orthopedics, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Medical Devices, Technology Classifications > Invention Type > Medical Devices > Imaging

Nanoparticles Targeting Gene Editing Systems to Cancer Cells

Nanoparticles Targeting Gene Editing Systems to Cancer Cells Targeted gene therapy delivery platform for oncology indications with stable nanoparticles and no cytotoxicity Background To date, existing gene editing delivery systems involve viral vectors or cationic materials, which carry a high human safety concern. Researchers at Boston Children’s...

Published: 6/30/2025 | Updated: 5/5/2023 | Inventor(s): Marsha Moses, Peng Guo, Jiang Yang, Debra Auguste

Keywords(s): Cancer, Gene Therapy, Oncology, Viral Vector