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A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
Background
Limited options exist for the effective treatment of Atopic dermatitis (AD), a common inflammatory condition affecting 20% of infants and children, due to a lack of understanding of specific treatment targets for AD. An improved genomic understanding of AD is needed...
Published: 9/16/2025
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Updated: 7/17/2023
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Inventor(s): Xi He, Maorong Chen, Nathalia Amado
Keywords(s): Common, Dermatology, Rheumatology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Novel Bacteriotherapies for the prevention and treatment of Food Allergy
Novel Bacteriotherapies for the prevention and treatment of Food Allergies
Background
Most food allergies are acquired in the first years of life, indicating a critical role for early childhood exposures in disease pathogenesis. Reduced bacterial diversity and an impaired ratio of specific bacteria in infancy have been associated with food sensitization,...
Published: 3/20/2026
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Updated: 7/11/2023
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Inventor(s): Talal Chatila, Azza Abdel-Gadir, Emmanuel Stephen Victor, Rima Rachid, Lynn Bry, Georg Gerber
Keywords(s): Allergy, Common, Food Allergy, Immunology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Microbiome, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology > Allergy
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A novel antibody drug conjugate to treat pancreatic cancer
Novel Antibody Conjugate to Treat Pancreatic Cancer
Background
Pancreatic cancer (PC) represents 7% of all cancer mortalities and has a strikingly poor prognosis with PC patients having a 5-year survival rate of less than 8% despite recently intensified studies of immunotherapy and nanomedicine therapy. The immunosuppressive microenvironment of pancreatic...
Published: 6/26/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Jing Huang, Peng Guo
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
Background
Breast cancer is the most common cancer in women. It accounts for 12.5% of all cancers globally and women in the United States have a 1 in 8 chance of developing breast cancer. While the 5-year survival is about 90% for...
Published: 6/30/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Peng Guo, Jing Huang, Jianmin Fang
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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