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TLR7/8 Ligands for Use in Opioid Vaccines

TLR7/8 Ligands for Use in Opioid Vaccines Ligands with the potential for preventing fatal overdose of opioid users and protect against or treat Opioid Use Disorder patients Technology Overview Building on their work as part of the Precision Vaccines Program, researchers in the Levy lab have developed a method of enhancing immune response to anti-opioid...

Published: 3/24/2026 | Updated: 3/24/2026 | Inventor(s): Ofer Levy, David Dowling, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni

Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines

Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology

Engineered Antibody Class Switch Recombination

Engineered Antibody Class Switch Recombination Enables the production of antibodies with identical epitopes with any desired constant region or without a constant region Background Class switch recombination (CSR) occurs during the normal maturation of B-cells. The initial step of CSR is the binding of an antigen to the B-cell surface-expressed immunoglobulin...

Published: 3/20/2026 | Updated: 3/6/2023 | Inventor(s): Roberto Chiarle, Taek-Chin Cheong

Keywords(s): ZZCommon, ZZR&D Tools & Services:Procedure/ Protocol/ Process, ZZResearch / Development Tools & Services

Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology

TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine

TLR7/8 Adjuvant Overcomes Newborn Hyporesponsiveness to Pneumococcal Conjugate Vaccine The molecule 3M-052 offers effective immunization with one birth dose, representing a new paradigm in early life vaccine development Technology Overview Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical...

Published: 3/24/2026 | Updated: 3/6/2023 | Inventor(s): Ofer Levy, David Dowling, Jay Evans, Helene Brazin-Lee, David Burkhart, Alyson Smith

Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines

STING Agonists as Immunomodulators and Vaccine Adjuvants

STING Agonists as Immunomodulators and Vaccine Adjuvants STING agonists proven to be effective vaccine adjuvants and immunomodulators in newborns Background Infectious diseases are the leading cause of morbidity and mortality in early life and immunization is a key preventive strategy. Vaccine adjuvants can enhance, prolong, and modulate immune responses...

Published: 3/30/2026 | Updated: 3/6/2023 | Inventor(s): Ofer Levy, Carlo Pietrasanta, David Dowling, Francesco Borriello

Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines

Biomarkers of Neuropathic Pain

Biomarkers of Neuropathic Pain They can be used to access neuropathic pain, diagnostics, clinical trials and in assessing therapeutic intervention for treating pain Background Pain is a sensory disturbance that is very difficult to measure accurately based on patients' subjective reports. There is an enormous need for objective and sensitive...

Published: 9/16/2025 | Updated: 2/15/2023 | Inventor(s): Clifford Woolf, Alban Latremoliere, Alexandre Chloe, Thomas Scammell

Keywords(s): Diagnostics, ZZCommon

Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers

Anisotropic Material Testing Device

Anisotropic Material Testing Device A series of force-controlled multiaxial loading devices for the purpose of characterizing bio-materials Background The stress-testing of biomaterials is crucial for the evaluation of their durability and suitability as medical implants. It is pivotal to simulate the forces that biomaterials will be exposed to under...

Published: 7/22/2025 | Updated: 1/6/2023 | Inventor(s): David Hoganson, Peter Hammer, Nick Kneier, Christopher Payne

Keywords(s): ZZCommon

Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Research Tools, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Cardiology