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Thermo-sensitive penetration-enhancing formulations for trans-tympanic and transdermal drugs delivery
Thermo-sensitive penetration-enhancing formulations for trans-tympanic and transdermal drug delivery
Background
Acute otitis media is one of the most common childhood diseases in the United States and present treatment of ear infections consists of systemic oral antibiotics, however these present many issues including antibiotic resistance and gastrointestinal...
Published: 3/23/2026
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Updated: 12/5/2025
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Inventor(s): Daniel Kohane, Zipei Zhang
Keywords(s): Otitis Media
Category(s): Technology Classifications > Disease Area > Otolaryngology, Technology Classifications > Disease Area > Anesthesia, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Modified liposomes for improved drug loading and sustained drug release
Modified liposomes for improved drug loading and sustained drug release
Background
Liposomes are a promising method of drug delivery, offering better properties than traditional drug delivery systems. However, despite having better site-targeting, protection from drug degradation, improved sustained or controlled release, and lower toxicity, some...
Published: 3/30/2026
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Updated: 3/28/2025
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Inventor(s): Daniel Kohane, Yang Li
Keywords(s): Analgesic/Anesthetic, Drug Delivery
Category(s): Technology Classifications > Disease Area > Anesthesia, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Aptamer as drug delivery vehicle for Site-1 Sodium Channel Blocking agents.
Aptamer as drug delivery vehicle for Site-1 Sodium Channel Blocking agents
Background
Aptamers are small, short, single-stranded molecules of DNA or RNA or peptides. They act like chemical “keys” that can find and attach to specific “locks” on certain molecules. This biological mechanism is called antibody-antigen interaction;...
Published: 3/30/2026
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Updated: 1/17/2024
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Inventor(s): Daniel Kohane, Dali Wang, Christopher Weldon, Xiangang Huang
Keywords(s):
Category(s): Technology Classifications > Disease Area > Surgery, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Background
Blood coagulation is an essential physiological process where the blood changes from a liquid form into a thicker, gel-like form in response to a blood vessel injury thereby preventing excessive blood...
Published: 6/26/2025
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Updated: 6/21/2023
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Inventor(s): Daniel Kohane, Juan Ibla, Upendra Katneni, Chava Kimchi-Sarfaty
Keywords(s): Cardiovascular, Molecules/ Proteins, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Protein
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