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Microglia for scar-less healing, protection, and regeneration in the CNS
Microglia for scar-less healing, protection, and regeneration in the CNS
Background
Neuron injuries associated with neurodegenerative diseases, neuroinflammation, or physical spinal cord injury have very limited therapeutic options. These pathological conditions are often permanent and include cognitive decline, persistent physical pain, paralysis,...
Published: 10/6/2025
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Updated: 5/28/2025
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Inventor(s): Zhigang He, Yi Li, Xuelian He
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Specialized adeno-associated virus for central nervous system gene therapy
Specialized adeno-associated virus for central nervous system gene therapy
Background
Unlike other cell types in the human body, nerve cells (neurons) have an extremely limited ability to replace themselves through division following damage to the nervous system. Most injuries and diseases of the central nervous system (CNS) involve damage to axons,...
Published: 9/16/2025
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Updated: 6/9/2023
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Inventor(s): Zhigang He, Xue Yao, Zicong Zhang, Benedikt Brommer
Keywords(s): CNS, Gene Therapy, Therapeutic, Trauma
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Gene Expression Signature that Identifies DNA Repair and Predicts Tumor Sensitivity to Drugs
Gene Expression Signature that Identifies DNA Repair and Predicts Tumor Sensitivity to Drugs
Genotoxic chemotherapy to treat cancers with impaired DNA damage repair pathways
Technology Overview
Genotoxic chemotherapy, one of the most widely-used cancer treatment strategies, forces cells to undergo apoptosis in response to DNA damage. Genotoxic chemotherapy...
Published: 3/30/2026
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Updated: 5/5/2023
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Inventor(s): Zoltan Szallasi, Andrea Richardson, Nicolai Birkbak, Zhigang Wang
Keywords(s):
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Diagnostics
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Novel Therapeutic Target to Treat Nerve Damage by Promoting Neuronal Survival and Regeneration
Novel Therapeutic Target to Treat Nerve Damage by Promoting Neuronal Survival and Regeneration
The therapeutic stimulates nerve regeneration and can potentially reverse nerve damage
Background
Treating spinal cord and other central nervous system injuries remains a major challenge for neuroscience. These injuries sever axonal connections, which cannot...
Published: 9/16/2025
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Updated: 2/15/2023
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Inventor(s): Zhigang He, Thomas Schwarz, Romain Cartoni
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology
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