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Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease

Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease Background Alzheimer’s disease (AD) is the sixth-leading cause of death in the United States. It represents a major health challenge due to the following: Population aging is associated with increased prevalence of dementia, with...

Published: 3/27/2026 | Updated: 7/17/2023 | Inventor(s): Hanno Steen, Patrick Van Zalm, Judith Steen

Keywords(s): CNS

Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers

Specialized adeno-associated virus for central nervous system gene therapy

Specialized adeno-associated virus for central nervous system gene therapy Background Unlike other cell types in the human body, nerve cells (neurons) have an extremely limited ability to replace themselves through division following damage to the nervous system. Most injuries and diseases of the central nervous system (CNS) involve damage to axons,...

Published: 9/16/2025 | Updated: 6/9/2023 | Inventor(s): Zhigang He, Xue Yao, Zicong Zhang, Benedikt Brommer

Keywords(s): CNS, Gene Therapy, Therapeutic, Trauma

Methods and compositions for treating ataxia telangiectasia

Methods and compositions for treating ataxia telangiectasia Background Ataxia telangiectasia (A-T) is an incurable autosomal recessive disease that occurs in 1 in 40,000 to 100,000 people worldwide. It is caused by mutations in the Ataxia Telangiectasia Mutated (ATM) gene. A-T is characterized by neurodegeneration in the central nervous system, immune...

Published: 6/26/2025 | Updated: 5/30/2023 | Inventor(s): Timothy Yu, Jinkuk Kim

Keywords(s): CNS, Gene Therapy, Genetic Disorder, Rare Disease

Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > ASOs, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Neurology

Oligonucleotide approach to treat exon skipping diseases

Oligonucleotide approach to treat exon skipping diseases Background Almost half of mammalian genomes contain repeat DNA sequences known as transposable elements (TE) or transposons. Many transposons have the ability to mobilize and change location in the genome, yet their role in human health and disease is not well defined. RNA transposons (i.e.,...

Published: 3/20/2026 | Updated: 5/30/2023 | Inventor(s): Timothy Yu, Alice Lee

Keywords(s): CNS, Gene Therapy, Genetic Disorder, Rare Disease