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Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Background
Epilepsy is a chronic neurological condition that affects over 50 million people worldwide. Mesial temporal lobe epilepsy (MTLE), the most common focal epilepsy, is characterized by recurrent focal seizures, memory issues, risk of injury due to recurrent...
Published: 3/23/2026
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Updated: 7/29/2025
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Inventor(s): Christopher Walsh, Kristopher Kahle, Sattar Khoshkhoo, Alice Lee, (Elain) Yilan Wang
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
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Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains
Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease
Background
Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...
Published: 3/23/2026
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Updated: 4/3/2025
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Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Oligonucleotide approach to treat exon skipping diseases
Oligonucleotide approach to treat exon skipping diseases
Background
Almost half of mammalian genomes contain repeat DNA sequences known as transposable elements (TE) or transposons. Many transposons have the ability to mobilize and change location in the genome, yet their role in human health and disease is not well defined. RNA transposons (i.e.,...
Published: 3/20/2026
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Updated: 5/30/2023
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Inventor(s): Timothy Yu, Alice Lee
Keywords(s): CNS, Gene Therapy, Genetic Disorder, Rare Disease
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > ASOs, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Neurology
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