|
Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Background
Aging in humans brings increased incidence of nearly all diseases, including neurodegeneration. Markers of DNA damage increase in the brain with age, and genetic progeroid diseases such as Cockayne syndrome (CS) and Xeroderma pigmentosum (XP), both...
Published: 3/23/2026
|
Updated: 12/5/2025
|
Inventor(s): Christopher Walsh, Rachel Rodin, Michael Coulter, Peter Park, Craig Bohrson, Alison Barton, Minseok Kwon, Michael Lodato
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics
|
|
Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Background
Epilepsy is a chronic neurological condition that affects over 50 million people worldwide. Mesial temporal lobe epilepsy (MTLE), the most common focal epilepsy, is characterized by recurrent focal seizures, memory issues, risk of injury due to recurrent...
Published: 3/23/2026
|
Updated: 7/29/2025
|
Inventor(s): Christopher Walsh, Kristopher Kahle, Sattar Khoshkhoo, Alice Lee, (Elain) Yilan Wang
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
|
|
Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains
Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease
Background
Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...
Published: 3/23/2026
|
Updated: 4/3/2025
|
Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
|
|
Rapid Methods for Precise Validation of Germline and Mosaic Genetics Mutations
Rapid Methods for Precise Validation of Germline and Mosaic Genetics Mutations
This invention provides a rapid, precise, and sensitive approach for identifying and validating genetic mutations
Background
Previous methods and studies have clearly shown the important role of mosaic mutations in disease pathogenesis but quantifying the exact level...
Published: 3/9/2026
|
Updated: 3/10/2023
|
Inventor(s): Ryan Doan, Christopher Walsh
Keywords(s):
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Research Tools, Technology Classifications > Invention Type > Research Tools > Assay
|
