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Targeting the Super Elongation Complex to Prevent Hematopoietic Stem Cell Expansion and Blood Cancer Risk
Targeting the Super Elongation Complex to Prevent Hematopoietic Stem Cell Expansion and Blood Cancer Risk
Background
It is estimated that over 1.7 million people in the United States are living with or in remission from blood cancers such as leukemias, lymphomas, myeloma, and myeloproliferative neoplasms (MPNs), and approximately 192,070 new cases...
Published: 3/26/2026
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Updated: 12/19/2025
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Inventor(s): Vijay Sankaran, Jiawei Zhao, Liam Cato
Keywords(s): Blood Cancer
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Novel Targets
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Expanding HSCs by blocking ferroptosis
Expanding HSCs by blocking ferroptosis
Background
Hematopoietic stem cell (HSC) transplant is a common life-saving treatment for several hematological and immunological disorders, including leukemia, bone marrow failure syndromes, and immunodeficiencies. To date, over 1.5 million HSC transplants have been performed, making it a widespread therapeutic...
Published: 3/26/2026
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Updated: 10/9/2025
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Inventor(s): Vijay Sankaran, Lucrezia Della Volpe
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Gene Editing
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Genetic regulators of fetal hemoglobin
Genetic Regulators of fetal hemoglobin
Background
During human development, the major hemoglobin in red blood cells changes from fetal hemoglobin (HbF, α₂γ₂) to adult hemoglobin (HbA, α₂β₂) shortly after birth. This change, known as the fetal-to-adult hemoglobin switch, involves a transcriptional shift from the γ-globin...
Published: 3/26/2026
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Updated: 11/20/2024
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Inventor(s): Vijay Sankaran, Liam Cato, Rick Li, Yi-Chin Lu, Chun-Jie Guo
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Disease Area > Hematology, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Invention Type > Novel Targets
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GATA1 Gene Therapy for Diamond-Blackfan Anemia
GATA1 Gene Therapy for Diamond-Blackfan Anemia
A unified lentiviral vector based gene therapy approach, which has potential to treat DBA in all patients
Background
Diamond-Blackfan anemia (DBA) is a rare inherited disorder that that occurs when the bone marrow fails to make red blood cells, thereby leading to severe anemia.
Current therapeutic options...
Published: 3/26/2026
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Updated: 3/9/2023
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Inventor(s): Vijay Sankaran, Leif Ludwig, Richard Voit, David Williams
Keywords(s):
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Gene Therapy
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Novel and Highly Efficient Production of Red Blood Cells
Novel and Highly Efficient Production of Red Blood Cells
A new method to boost the efficiency of ex vivo production of red blood cells by silencing the gene SH2B3
Background
Transfusion of red blood cells (RBCs) is an extremely common medical procedure used for a variety of lifesaving applications. However, the supply of RBCs is completely dependent...
Published: 3/27/2026
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Updated: 1/6/2023
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Inventor(s): Vijay Sankaran
Keywords(s):
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Hematology
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