Search Results - luk.kevin

2 Results Sort By:
Advancing Hemoglobinopathy Care: Innovative BCL11A Inhibition for Sustained Fetal Hemoglobin Production
Advancing Hemoglobinopathy Care: Innovative BCL11A Inhibition for Sustained Fetal Hemoglobin Production Background Hemoglobinopathies, including sickle cell anemia and β-thalassemias, are genetic disorders caused by mutations that impair the production or structure of of β-globin chains in hemoglobin. These conditions result in patients...
Published: 3/25/2026   |   Updated: 12/5/2025   |   Inventor(s): Daniel Bauer, Yuxuan Wu, Jing Zeng, Scot Wolfe, Mehmet Bolukbasi, Benjamin Roscoe, Pengpeng Liu, Luk.Kevin
Keywords(s): Sickle Cell Anemia
Category(s): Technology Classifications > Invention Type > Therapeutics > Gene Therapy, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Therapeutics > Gene Editing
Genetic regulators of fetal hemoglobin
Genetic Regulators of fetal hemoglobin Background During human development, the major hemoglobin in red blood cells changes from fetal hemoglobin (HbF, α₂γ₂) to adult hemoglobin (HbA, α₂β₂) shortly after birth. This change, known as the fetal-to-adult hemoglobin switch, involves a transcriptional shift from the γ-globin...
Published: 3/26/2026   |   Updated: 11/20/2024   |   Inventor(s): Vijay Sankaran, Liam Cato, Rick Li, Yi-Chin Lu, Chun-Jie Guo
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Disease Area > Hematology, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Invention Type > Novel Targets