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Application of novel enterococcus pore-forming toxins
Advancing Treatment for Antibiotic-Resistant Infections with Enterococcus Pore-Forming Toxin Technology
Background
Enterococcus faecalis and Enterococcus faecium have emerged as significant contributors to multidrug-resistant (MDR) infections, posing a substantial threat to public health due to their inherent and acquired resistance to antibiotics....
Published: 3/20/2026
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Updated: 10/6/2025
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Inventor(s): Min Dong, Xiaozhe Xiong, Songhai Tian
Keywords(s):
Category(s): Technology Classifications > Invention Type > Research Tools > Protein (Research Tool), Technology Classifications > Invention Type > Therapeutics > Peptide, Technology Classifications > Disease Area > Infectious Disease
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Biofilm Matrix Boosted Vaccine
Biofilm Matrix Boosted Vaccine
Background
Bacterial biofilm formation is a process in which bacteria adhere to a surface, creating single or multilayer structures. The biofilm matrix consists of exopolysaccharides, proteins, and DNA. In contrast to the conventional belief that biofilm exopolysaccharides primarily serve as adhesive materials for binding...
Published: 3/20/2026
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Updated: 3/10/2025
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Inventor(s): Paula Watnick, Julie Liao
Keywords(s):
Category(s): Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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The adjuvant combination PVP-AF04 enhances the antibody response towards SARS-CoV antigens
The adjuvant combination PVP-AF04 enhances the antibody response towards SARS-CoV antigens
Background
As of 2024, SARS-CoV-2 has caused over 1 million deaths in the United States and more than 7 million worldwide. As the virus continues to mutate, it is important to advance immunization efforts to combat the virus’s effects, especially...
Published: 3/24/2026
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Updated: 5/8/2024
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Inventor(s): Ofer Levy, Yoshine Saito, Francesco Borriello, David Dowling, Timothy Yu
Keywords(s):
Category(s): Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19, Technology Classifications > Invention Type > Vaccines > Adjuvants
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RETRA-Seq to inform antibiotic therapy of resistant bacteria
RETRA-Seq to inform antibiotic therapy of resistant bacteria
Background
Severe bacterial infections, characterized by their resistance to multiple antibiotics, are common in hospital-admitted patients and can lead to the development of severe infections, such as pneumonia or systemic septicemia, which are the leading cause of death in these...
Published: 3/20/2026
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Updated: 2/22/2024
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Inventor(s): Gregory Priebe, Roy Kishony, Hattie Chung, Matthew Schaefers
Keywords(s):
Category(s): Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Diagnostics
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SARS-COV-2 Antigen Nanoparticles and Uses Thereof
SARS-COV-2 Antigen Nanoparticles and Uses Thereof
Background
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel betacoronavirus, has caused a global health crisis and still poses a substantial risk to public health, leading to over 103 million reported infections in the United States and over 774 million worldwide since 2019. The...
Published: 3/24/2026
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Updated: 2/13/2024
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Inventor(s): Ofer Levy, Francesco Boriello, David Dowling, Sirano Dhe-Pagnon, Hyuk-Su Seo, David Scott, Frederic Feru
Keywords(s):
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Invention Type > Vaccines > Adjuvants
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Lipid Gb3 as an adjuvant for anti-viral vaccination
Lipid Gb3 as adjuvant for anti-viral vaccination
Background
Adjuvants are vaccine components added to enhance the magnitude, breadth, and durability of response.
Selection of appropriate adjuvants requires improved understanding of immune responses to pathogens/antigens by B cells (white blood cells). B cells develop in the bone marrow and are...
Published: 3/23/2026
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Updated: 1/12/2024
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Inventor(s): Florian Winau, Pankaj Sharma
Keywords(s): Adjuvants, Immunology
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Vaccines > Adjuvants
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Intubation Shield - a foldable plastic shield that can be placed on the patient to protect the intubator and other healthcare workers in the room during intubation.
Intubation Shield: A foldable plastic shield to protect the patient and healthcare workers during intubation
Background
The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted global human health and is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This novel virus was first identified in China in...
Published: 3/27/2026
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Updated: 8/14/2023
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Inventor(s): Farokh Demehri, Heung Kim, Robert Crum, Brianna Slatnick, Kyle Wu, Alexander Yang, Pete Kovatsis, Nathaniel Tighe, Jonathan Durgin
Keywords(s): Medical Device, Respiratory
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Medical Devices, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19
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MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
Background
Though vaccination is one of the greatest accomplishments of modern medicine, there are still challenges to the production of perfectly effective vaccines. These challenges include weakened response by the vaccinated individual’s immune system...
Published: 3/24/2026
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Updated: 5/31/2023
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Inventor(s): Simon van Haren, Ofer Levy, Guzman Sanchez-Schmitz, David Dowling
Keywords(s): Drug Delivery, Immunology, Infectious Disease, Vaccine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Research Tools, Technology Classifications > Invention Type > Research Tools > Assay, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease
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Toll-like receptor 2 agonists as vaccine adjuvants
Toll-like receptor 2 agonists as vaccine adjuvants
Background
Vaccinations play an essential role in preventing infections in the population, reducing the number of deaths in vulnerable individuals, as well as preventing endemics of highly infectious diseases. Because of the protective nature of vaccinations, particularly for those in certain vulnerable...
Published: 3/24/2026
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Updated: 5/31/2023
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Inventor(s): Ofer Levy, David Dowling, Francesco Borriello, Spencer Brightman
Keywords(s): Adjuvants, Infectious Disease, Vaccine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Oncology
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Instranasal Delivery of Apilimod and Nafamostat for the Treatment of COVID
Intranasal Delivery of Apilimod and Nafamostat for the Treatment of COVID
Unmet Need
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic and has profoundly impacted global human health. Since its initial discovery in 2019, several viral variants have caused additional outbreaks...
Published: 6/26/2025
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Updated: 5/23/2023
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Inventor(s): Tomas Kirchhausen, Alex Kreutzberger, Giuseppe Balistreti
Keywords(s): Combination Therapy, Drug Repurposing
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19
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