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Targeting Gasdermin for Management of Inflammatory Diseases and Cancer

Targeting Gasdermin for Management of Inflammatory Diseases and Cancer Background Inflammation is a key factor in numerous diseases, including sepsis, inflammatory bowel disease, Alzheimer’s disease, and cancer. Millions worldwide are affected by these conditions, with sepsis affecting over 49 million people annually and Alzheimer’s impacting...

Published: 3/23/2026 | Updated: 3/9/2026 | Inventor(s):

Keywords(s):

Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Immunology > Inflammation, Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease

Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains

Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease Background Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...

Published: 3/23/2026 | Updated: 4/3/2025 | Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang

Keywords(s): Neurodegeneration

Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease