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Enhancement of extravasation and fusion factors to enable cellular therapy for Muscular dystrophies
Enhancement of extravasation and fusion factors to enable cellular therapy for Muscular dystrophies
Background
Muscular dystrophies are incurable diseases for which cell-based therapies present a promising therapeutic option. While the root cause of all muscular dystrophies is genetic, gene therapy alone cannot reverse existing muscle degeneration,...
Published: 3/23/2026
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Updated: 11/29/2025
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Inventor(s): Louis Kunkel, Angela Lek, Janelle Spinazzola, Yuanfan Zhang
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area > Genetics & Genomics
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(3284, 4360) Niche endothelial cell technology to create red blood stem cells
Engineering Endothelial Niche Cells for Enhanced HSPC Expansion and Transplantation
Background
Haematopoietic stem and progenitor cells (HSPCs) offer a curative potential for various blood and immune diseases through transplantation. Their success, however, is limited by the scarcity of immune-matched donors. Efforts in in vitro expansion of HSPCs...
Published: 3/6/2026
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Updated: 11/4/2025
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Using defined factors to engineer niche endothelial cells for growing and maintaining blood stem cells
Use of engineered niche endothelial cells to grow and maintain blood stem cells
Background
Hematopoietic stem and progenitor cells (HSPCs) are a rare cell population found in bone marrow that are responsible for producing all blood and immune cells. These cells are especially valuable for their ability to regenerate the entire blood system after transplantation...
Published: 3/25/2026
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Updated: 11/4/2025
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Inventor(s): Leonard Zon, Elliott Hagedorn
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Innovative Immunotherapy for HER2-Positive Breast Cancer: Harnessing Engineered B Cells
Innovative Immunotherapy for HER2-Positive Breast Cancer: Harnessing Engineered B Cells
Background
Breast cancer, particularly the subtype overexpressing the HER2 gene, presents a significant unmet medical need due to severe therapeutic challenges. Roughly 15-20% of all breast cancer cases exhibit overexpression or amplification of HER2, a tyrosine...
Published: 3/26/2026
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Updated: 10/13/2025
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Inventor(s): Pietro Genovese, Lucia Sereni, Andrea Bianchi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Hematopoietic Stem Cell Transplantation: Enhanced Engraftment without Chemotherapy for Genetic and Acquired Disorders
Hematopoietic Stem Cell Transplantation: Enhanced Engraftment without Chemotherapy for Genetic and Acquired Disorders
Background
There is a crucial unmet medical need for improved methods to treat inherited and acquired diseases via hematopoietic stem cell transplantation. Currently, patients must undergo high-dose alkylating chemotherapy as part...
Published: 3/26/2026
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Updated: 10/9/2025
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Inventor(s): Daniel Bauer, Vivien Schoonenberg, Sabine Studer, Sebastien Levesque
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area > Hematology
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Advanced Method for Producing Natural Killer Cells from Pluripotent Stem Cells for Cancer Immunotherapy
Advanced Method for Producing Natural Killer Cells from Pluripotent Stem Cells for Cancer Immunotherapy
Background
Cancer remains a significant global health challenge, with millions of individuals affected by various types of the disease each year. The standard of care typically involves surgery, chemotherapy, and radiation therapy, often resulting...
Published: 3/26/2026
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Updated: 10/6/2025
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Inventor(s): George Daley, Deepak Jha, Mohammad Najia
Keywords(s):
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Extracellular vesicles as an antenatal treatment for the prevention of pregnancy loss, preeclampsia and fetal growth restriction.
Innovative Antenatal Therapy: Harnessing Mesenchymal Stem Cell Exosomes for Treating Placental Insufficiency and Preeclampsia
Background
Placental insufficiency and its complications, such as preeclampsia, pose significant challenges in maternal and fetal healthcare. Affecting millions globally, these conditions can lead to long-term neurological,...
Published: 3/23/2026
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Updated: 7/29/2025
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis, Elizabeth Taglauer
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Disease Area > Reproductive Health > Prenatal Care
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Microglia for scar-less healing, protection, and regeneration in the CNS
Microglia for scar-less healing, protection, and regeneration in the CNS
Background
Neuron injuries associated with neurodegenerative diseases, neuroinflammation, or physical spinal cord injury have very limited therapeutic options. These pathological conditions are often permanent and include cognitive decline, persistent physical pain, paralysis,...
Published: 10/6/2025
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Updated: 5/28/2025
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Inventor(s): Zhigang He, Yi Li, Xuelian He
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Background
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants related to oxygen exposure or mechanical ventilation of the developing, immature lungs. BPD occurs approximately...
Published: 3/24/2026
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Updated: 12/20/2024
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Fetal/Newborn Medicine, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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HPSC-derived articular chondrocyte compositions, system and methods of use thereof cross-reference to related applications
HPSC-derived articular chondrocyte compositions, system and methods of use thereof cross-reference to related applications
Background
Degenerative joint disease (osteoarthritis) is among the top five most costly medical conditions in the United States. One of the challenges of repairing the articular cartilage that lines our joints is that this...
Published: 3/27/2026
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Updated: 11/21/2024
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Inventor(s): April Craft, Jenna Galloway, Steven Pregizer
Keywords(s):
Category(s): Technology Classifications > Disease Area > Orthopedics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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