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TLR7/8 Ligands for Use in Opioid Vaccines
TLR7/8 Ligands for Use in Opioid Vaccines
Ligands with the potential for preventing fatal overdose of opioid users and protect against or treat Opioid Use Disorder patients
Technology Overview
Building on their work as part of the Precision Vaccines Program, researchers in the Levy lab have developed a method of enhancing immune response to anti-opioid...
Published: 3/24/2026
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Updated: 3/24/2026
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Inventor(s): Ofer Levy, David Dowling, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Controlling pH-Dependent Condensates for Cellular Response
Controlling pH-Dependent Condensates for Cellular Response
Background
Inflammation is a vital part of the body’s defense mechanisms, ensuring homeostasis and protecting the integrity of tissues and organs. However, excessive inflammatory responses can lead to severe tissue damage. Despite existing treatments, the fine control over inflammatory...
Published: 3/30/2026
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Updated: 10/6/2025
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Inventor(s): Xu Zhou, Zhongyang Wu
Keywords(s):
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Invention Type > Novel Targets
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Targeting the ATP/P2X7R axis to prevent and treat type 1 diabetes, allograft rejection, lung fibrosis and aging
Targeting the ATP/P2X7R axis to prevent and treat type 1 diabetes, allograft rejection, lung fibrosis and aging
Background
Insulin therapy, the current standard treatment for type 1 diabetes (T1D) cannot fully prevent the severe complications related to the disease which include kidney failure and coronary heart disease. Successful islet transplantation...
Published: 3/6/2026
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Updated: 4/11/2025
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Disease Area > Autoimmune, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Transplant, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Macrophage Immunomodulation by Mesenchymal Stem Cell Exosome Treatment and Restoration of Lung Architecture in Models of Bronchopulmonary Dysplasia
Background
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants related to oxygen exposure or mechanical ventilation of the developing, immature lungs. BPD occurs approximately...
Published: 3/24/2026
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Updated: 12/20/2024
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s):
Category(s): Technology Classifications > Disease Area > Pulmonary, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Fetal/Newborn Medicine, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Production of T-cells using engineered soluble DLL4 ligands
Production of T cells using engineered soluble DLL4 ligands
Background
Chimeric Antigen Receptor T-cell (CAR T-cell) therapies are a therapeutic tool for the treatment of several types of cancers, most notably lymphomas and leukemia. Healthy T cells are taken from the patient’s blood, cultured in the laboratory to induce differentiation, and...
Published: 3/26/2026
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Updated: 11/20/2024
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Inventor(s): Rubul Mout, Ran Jing, George Daley, Stephen Blacklow, David Baker, Emily Egan
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Cell Therapy, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Hematology
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SARS-COV-2 Antigen Nanoparticles and Uses Thereof
SARS-COV-2 Antigen Nanoparticles and Uses Thereof
Background
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel betacoronavirus, has caused a global health crisis and still poses a substantial risk to public health, leading to over 103 million reported infections in the United States and over 774 million worldwide since 2019. The...
Published: 3/24/2026
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Updated: 2/13/2024
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Inventor(s): Ofer Levy, Francesco Boriello, David Dowling, Sirano Dhe-Pagnon, Hyuk-Su Seo, David Scott, Frederic Feru
Keywords(s):
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Invention Type > Vaccines > Adjuvants
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Lipid Gb3 as an adjuvant for anti-viral vaccination
Lipid Gb3 as adjuvant for anti-viral vaccination
Background
Adjuvants are vaccine components added to enhance the magnitude, breadth, and durability of response.
Selection of appropriate adjuvants requires improved understanding of immune responses to pathogens/antigens by B cells (white blood cells). B cells develop in the bone marrow and are...
Published: 3/23/2026
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Updated: 1/12/2024
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Inventor(s): Florian Winau, Pankaj Sharma
Keywords(s): Adjuvants, Immunology
Category(s): Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Vaccines > Adjuvants
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A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
Background
Limited options exist for the effective treatment of Atopic dermatitis (AD), a common inflammatory condition affecting 20% of infants and children, due to a lack of understanding of specific treatment targets for AD. An improved genomic understanding of AD is needed...
Published: 9/16/2025
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Updated: 7/17/2023
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Inventor(s): Xi He, Maorong Chen, Nathalia Amado
Keywords(s): Common, Dermatology, Rheumatology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
MEMPHIS: Modular Evaluation of immunogenicity using Multi-Platform Human In vitro Systems
Background
Though vaccination is one of the greatest accomplishments of modern medicine, there are still challenges to the production of perfectly effective vaccines. These challenges include weakened response by the vaccinated individual’s immune system...
Published: 3/24/2026
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Updated: 5/31/2023
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Inventor(s): Simon van Haren, Ofer Levy, Guzman Sanchez-Schmitz, David Dowling
Keywords(s): Drug Delivery, Immunology, Infectious Disease, Vaccine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Research Tools, Technology Classifications > Invention Type > Research Tools > Assay, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Infectious Disease
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Engineered Antibody Class Switch Recombination
Engineered Antibody Class Switch Recombination
Enables the production of antibodies with identical epitopes with any desired constant region or without a constant region
Background
Class switch recombination (CSR) occurs during the normal maturation of B-cells. The initial step of CSR is the binding of an antigen to the B-cell surface-expressed immunoglobulin...
Published: 3/20/2026
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Updated: 3/6/2023
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Inventor(s): Roberto Chiarle, Taek-Chin Cheong
Keywords(s): ZZCommon, ZZR&D Tools & Services:Procedure/ Protocol/ Process, ZZResearch / Development Tools & Services
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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