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Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Background
Aging in humans brings increased incidence of nearly all diseases, including neurodegeneration. Markers of DNA damage increase in the brain with age, and genetic progeroid diseases such as Cockayne syndrome (CS) and Xeroderma pigmentosum (XP), both...
Published: 3/23/2026
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Updated: 12/5/2025
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Inventor(s): Christopher Walsh, Rachel Rodin, Michael Coulter, Peter Park, Craig Bohrson, Alison Barton, Minseok Kwon, Michael Lodato
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics
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Interpretable Sequential Multiple-Instance Learning for Medical Imaging
Interpretable Sequential Multiple-Instance Learning for Medical Imaging
Background
Machine learning has quickly gained relevance in the medical field for its ability to analyze complex datasets to increase diagnostic accuracy and is commonly used to analyze individual datasets of images such as x-rays, ultrasounds, and similar medical images. However,...
Published: 3/24/2026
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Updated: 11/29/2025
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Inventor(s): Hsin-Hsiao Wang, Michael Lingzhi Li, Xiaolong Luo
Keywords(s):
Category(s): Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Invention Type > Software > Imaging Software
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Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Background
Epilepsy is a chronic neurological condition that affects over 50 million people worldwide. Mesial temporal lobe epilepsy (MTLE), the most common focal epilepsy, is characterized by recurrent focal seizures, memory issues, risk of injury due to recurrent...
Published: 3/23/2026
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Updated: 7/29/2025
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Inventor(s): Christopher Walsh, Kristopher Kahle, Sattar Khoshkhoo, Alice Lee, (Elain) Yilan Wang
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
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Novel Electric Impedance Myography for Neurogenic Bladder Function Evaluation
Novel Electric Impedance Myography for Neurogenic Bladder Function Evaluation
Background
Neurogenic Bladder (NB) is a common condition where bladder control is lost due to damage to the nerves that control bladder function, leading to difficulties in emptying or holding urine. It may arise from damage to the brain, spinal cord, or nerves, form post...
Published: 3/24/2026
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Updated: 4/22/2025
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Inventor(s): Hsin-Hsiao Wang, Seward Rutkove
Keywords(s):
Category(s): Technology Classifications > Disease Area > Urology, Technology Classifications > Invention Type > Diagnostics
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Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains
Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease
Background
Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...
Published: 3/23/2026
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Updated: 4/3/2025
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Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Detection of epilepsy with analysis of electromagnetic signals (EEG)
Detection of epileptogenic brains with non-linear analysis of electromagnetic signals
Background
Epilepsy, one of the most prevalent chronic neurological diseases, affects approximately 0.6-1% of the general population and represents an economic burden of .1-1% of the total budget of health care systems in some parts of the world, with a significant...
Published: 3/30/2026
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Updated: 2/14/2025
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Inventor(s): William Bosl, Tobias Loddenkemper
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
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Barcode for dementia: A molecular signature of Alzheimer’s disease and other tauopathies using mass spectrometry
Diagnostics of various Tauopathies
Background
Dementia and other cognitive disorders are serious medical issues that are of increasing concern as the global population ages. Dementia is not a specific disease, but rather a descriptive term for a collection of symptoms that can be caused by several disorders affecting the brain. People with...
Published: 3/24/2026
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Updated: 6/3/2024
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Inventor(s): Judith Steen, Hanno Steen, Jan Muntel
Keywords(s):
Category(s): Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Disease Area > Neurology
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Cytokine and Cellular Biomarkers for Identification of Ulcerative Colitis and Crohn's Disease using Mass Cytometry
Cytokine and Cellular Biomarkers for Identification of Ulcerative Colitis and Crohn's Disease using Mass Cytometry
Background
Inflammatory bowel disease (IBD) is a chronic condition that can lead to long-lasting intestinal inflammation associated with significant local and systemic morbidity as well as a high social and economic burden....
Published: 3/30/2026
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Updated: 2/23/2024
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Inventor(s): Scott Snapper, Yelizaveta (Liza) Konnikova, Vanessa Mitsialis
Keywords(s):
Category(s): Technology Classifications > Disease Area > Autoimmune, Technology Classifications > Disease Area > Gastroenterology, Technology Classifications > Invention Type > Diagnostics
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RETRA-Seq to inform antibiotic therapy of resistant bacteria
RETRA-Seq to inform antibiotic therapy of resistant bacteria
Background
Severe bacterial infections, characterized by their resistance to multiple antibiotics, are common in hospital-admitted patients and can lead to the development of severe infections, such as pneumonia or systemic septicemia, which are the leading cause of death in these...
Published: 3/20/2026
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Updated: 2/22/2024
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Inventor(s): Gregory Priebe, Roy Kishony, Hattie Chung, Matthew Schaefers
Keywords(s):
Category(s): Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Invention Type > Diagnostics
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Methods and compositions for tauopathy diagnosis and treatment
Methods and Compositions for Tauopathy Diagnosis and Treatment
Specific cleavage characteristics of Tau seed competence associated with stress and inflammation in neurons in Alzheimer’s disease.
Background
The monomeric Tau is a soluble cytosolic protein that can aggregate under pathological conditions to form highly organized, disease-specific...
Published: 9/16/2025
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Updated: 6/30/2023
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Inventor(s): Judith Steen, Pieter Beerepoot, Long Cheng, Hanno Steen, Mukesh Kumar, Waltraud Mair, Hendrik Wesseling
Keywords(s): Brain, Diagnostics, Neurology
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Diagnostics
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