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PAD4 Inhibitor Therapy for Managing Heart Failure and Diabetic Complications
PAD4 Inhibitor Therapy for Managing Heart Failure and Diabetic Complications
Background
Heart failure and diabetic complications, including cardiomyopathy and nephropathy, are significant global health challenges affecting millions. Heart failure, specifically heart failure with preserved ejection fraction (HFpEF), is characterized by impaired heart...
Published: 3/25/2026
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Updated: 3/25/2026
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area > Cardiology, Technology Classifications > Disease Area > Cardiovascular
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Targeting Gasdermin for Management of Inflammatory Diseases and Cancer
Targeting Gasdermin for Management of Inflammatory Diseases and Cancer
Background
Inflammation is a key factor in numerous diseases, including sepsis, inflammatory bowel disease, Alzheimer’s disease, and cancer. Millions worldwide are affected by these conditions, with sepsis affecting over 49 million people annually and Alzheimer’s impacting...
Published: 3/23/2026
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Updated: 3/9/2026
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Inventor(s):
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Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Immunology > Inflammation, Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Novel Telomere Regulation Technology
Novel Telomere Regulation Technology
Background
Telomeres, protective caps at the ends of chromosomes, play a crucial role in maintaining cellular health. Their length is a key determinant of a cell's ability to replicate. Shortened telomeres, due to genetic mutations or acquired environmental insults, lead to telomerase dysfunction. This has...
Published: 3/23/2026
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Updated: 12/5/2025
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Inventor(s): Suneet Agarwal, Baris Boyraz, Neha Nagpal
Keywords(s): Aging, dyskeratosis congenita, Telomere
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Invention Type > Therapeutics > RNA (ie. mRNA, siRNA)
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A specific chemical and transcription factor combination specifies and expands hematopoietic stem and progenitor cells in zebrafish embryonic cell culture.
Method for Inducing Hematopoietic Stem Cell Specificity
Background
Hematopoietic stem cells (HSCs), found primarily in bone marrow, are crucial for blood cell formation and immune system function. While transplantation of allogeneic and autologous HSCs is common for treating various life-threatening disorders, the procedure carries high risks, primarily...
Published: 3/26/2026
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Updated: 11/4/2025
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Inventor(s): Leonard Zon, Joseph Mandelbaum, Anne Robertson
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Compounds Treating AP-4 Associated Hereditary Spastic Paraplegia
Compounds Treating AP-4 Associated Hereditary Spastic Paraplegia
Background
Hereditary Spastic Paraplegia (HSP) is a group of inherited neurological disorders characterized by progressive spasticity, weakness, and gait abnormalities and affects approximately 5-10 per 100,000 individuals worldwide. Among its subtypes, Adaptor Protein Complex 4 (AP-4)-related...
Published: 3/23/2026
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Updated: 7/28/2025
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Inventor(s): Darius Ebrahimi-Fakhari, Mustafa Sahin, Masato Satoh, Jed Hubbs
Keywords(s): Hereditary Spastic Parapeligia, Movement Disorder, Neuromuscular Disorder
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Targeting the ATP/P2X7R axis to prevent and treat type 1 diabetes, allograft rejection, lung fibrosis and aging
Targeting the ATP/P2X7R axis to prevent and treat type 1 diabetes, allograft rejection, lung fibrosis and aging
Background
Insulin therapy, the current standard treatment for type 1 diabetes (T1D) cannot fully prevent the severe complications related to the disease which include kidney failure and coronary heart disease. Successful islet transplantation...
Published: 3/6/2026
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Updated: 4/11/2025
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Category(s): Technology Classifications > Disease Area > Autoimmune, Technology Classifications > Disease Area > Immunology, Technology Classifications > Disease Area > Transplant, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Manipulation of nucleotides for telomere diseases
Novel Drug Target for Regulating Telomeres in Disease
Background
Human chromosomes, which carry genetic information and play an essential role in inheritance and normal tissue regeneration, are capped in structures called telomeres, which protect the chromosomes from fraying during the cell replication process. With each cell replication, telomeres...
Published: 3/26/2026
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Updated: 11/14/2024
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Inventor(s): Suneet Agarwal, William Mannherz
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Oncology
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A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
Background
Limited options exist for the effective treatment of Atopic dermatitis (AD), a common inflammatory condition affecting 20% of infants and children, due to a lack of understanding of specific treatment targets for AD. An improved genomic understanding of AD is needed...
Published: 9/16/2025
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Updated: 7/17/2023
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Inventor(s): Xi He, Maorong Chen, Nathalia Amado
Keywords(s): Common, Dermatology, Rheumatology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Instranasal Delivery of Apilimod and Nafamostat for the Treatment of COVID
Intranasal Delivery of Apilimod and Nafamostat for the Treatment of COVID
Unmet Need
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic and has profoundly impacted global human health. Since its initial discovery in 2019, several viral variants have caused additional outbreaks...
Published: 6/26/2025
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Updated: 5/23/2023
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Inventor(s): Tomas Kirchhausen, Alex Kreutzberger, Giuseppe Balistreti
Keywords(s): Combination Therapy, Drug Repurposing
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19
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Novel Antibiotic from a Costa Rican Fungus
Novel Antibiotic from a Costa Rican Fungus
Small-molecule antibiotic with activity against commonly drug-resistant species
Background
Antibiotic-resistant microbes have become a global problem, with an estimated 48,000 deaths attributed to resistant microbes in the U.S. and Europe alone. The constant threat of the development of resistance has led...
Published: 9/26/2025
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Updated: 5/5/2023
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Inventor(s): Paula Watnick, Patrick Ymele-Leki, Jon Clardy, Shugeng Cao
Keywords(s): Antibiotic, Research Tool, Small Molecule, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease
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