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Copper depletion for treatment of cancer in the brain (as a primary or secondary site)
Targeting Copper Metabolism to Improve Cancer Therapy Efficacy
Background
Acute Lymphoblastic Leukemia (ALL), one of the most common childhood cancers, is a type of cancer that originates in the bone marrow and can spread to various parts of the body, including the central nervous system (CNS) through cerebrospinal fluid. This can lead to deadly...
Published: 3/27/2026
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Updated: 12/17/2025
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Inventor(s): Naama Kanarek, Alan Wong
Keywords(s): Cancer
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Novel Targets
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Targeting prosaposin (pSAP) to dendritic cells as novel cancer immunotherapy
Targeting prosaposin (pSAP) to dendritic cells as novel cancer immunotherapy
Background
Antigen-specific T cell responses are central to protection against cancer. Abundance and proper function of immune cells, including lymphocytes and antigen-presenting cells such as dendric cells (DCs), at the tumor site are vital for effective immunity and control...
Published: 3/23/2026
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Updated: 11/29/2025
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Inventor(s): Florian Winau
Keywords(s):
Category(s): Technology Classifications > Disease Area > Hematology/Oncology, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Novel Targets
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Innovative Immunotherapy for HER2-Positive Breast Cancer: Harnessing Engineered B Cells
Innovative Immunotherapy for HER2-Positive Breast Cancer: Harnessing Engineered B Cells
Background
Breast cancer, particularly the subtype overexpressing the HER2 gene, presents a significant unmet medical need due to severe therapeutic challenges. Roughly 15-20% of all breast cancer cases exhibit overexpression or amplification of HER2, a tyrosine...
Published: 3/26/2026
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Updated: 10/13/2025
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Inventor(s): Pietro Genovese, Lucia Sereni, Andrea Bianchi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Advanced Method for Producing Natural Killer Cells from Pluripotent Stem Cells for Cancer Immunotherapy
Advanced Method for Producing Natural Killer Cells from Pluripotent Stem Cells for Cancer Immunotherapy
Background
Cancer remains a significant global health challenge, with millions of individuals affected by various types of the disease each year. The standard of care typically involves surgery, chemotherapy, and radiation therapy, often resulting...
Published: 3/26/2026
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Updated: 10/6/2025
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Inventor(s): George Daley, Deepak Jha, Mohammad Najia
Keywords(s):
Category(s): Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Manipulation of nucleotides for telomere diseases
Novel Drug Target for Regulating Telomeres in Disease
Background
Human chromosomes, which carry genetic information and play an essential role in inheritance and normal tissue regeneration, are capped in structures called telomeres, which protect the chromosomes from fraying during the cell replication process. With each cell replication, telomeres...
Published: 3/26/2026
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Updated: 11/14/2024
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Inventor(s): Suneet Agarwal, William Mannherz
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Oncology
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Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Background
Triple-negative (TNBC) and HER2+ breast cancers (BCs) are especially aggressive tumors with the worst prognosis as they are prone to relapse and metastasize post chemo- or targeted therapy. Immunotherapy provides...
Published: 3/9/2026
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Updated: 7/28/2023
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Inventor(s): Judy Lieberman, Ying Zhang
Keywords(s): Cancer, Oncology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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Synthetic genes that rewire natural immune pathways for anti-tumor defense
Synthetic genes that rewire natural immune pathways for anti-tumor defense
Background
Cancer is a malignant tumor resulting from the formation of abnormal cells in the body that can grow in an out-of-control fashion, eventually becoming fatal in the absence of effective, timely treatment. Interferons are a family of proteins that can naturally regulate...
Published: 3/9/2026
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Updated: 6/21/2023
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Inventor(s): Jonathan Kagan, Yunhao Tan
Keywords(s): Cancer, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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A novel antibody drug conjugate to treat pancreatic cancer
Novel Antibody Conjugate to Treat Pancreatic Cancer
Background
Pancreatic cancer (PC) represents 7% of all cancer mortalities and has a strikingly poor prognosis with PC patients having a 5-year survival rate of less than 8% despite recently intensified studies of immunotherapy and nanomedicine therapy. The immunosuppressive microenvironment of pancreatic...
Published: 6/26/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Jing Huang, Peng Guo
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
A rationally designed ICAM1 antibody drug conjugate for triple negative breast cancer and other ICAM1-expressing cancers
Background
Breast cancer is the most common cancer in women. It accounts for 12.5% of all cancers globally and women in the United States have a 1 in 8 chance of developing breast cancer. While the 5-year survival is about 90% for...
Published: 6/30/2025
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Updated: 6/9/2023
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Inventor(s): Marsha Moses, Peng Guo, Jing Huang, Jianmin Fang
Keywords(s): Common, Oncology, Therapeutic
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Large Molecule
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Toll-like receptor 2 agonists as vaccine adjuvants
Toll-like receptor 2 agonists as vaccine adjuvants
Background
Vaccinations play an essential role in preventing infections in the population, reducing the number of deaths in vulnerable individuals, as well as preventing endemics of highly infectious diseases. Because of the protective nature of vaccinations, particularly for those in certain vulnerable...
Published: 3/24/2026
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Updated: 5/31/2023
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Inventor(s): Ofer Levy, David Dowling, Francesco Borriello, Spencer Brightman
Keywords(s): Adjuvants, Infectious Disease, Vaccine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Oncology
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