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Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Background
Aging in humans brings increased incidence of nearly all diseases, including neurodegeneration. Markers of DNA damage increase in the brain with age, and genetic progeroid diseases such as Cockayne syndrome (CS) and Xeroderma pigmentosum (XP), both...
Published: 3/23/2026
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Updated: 12/5/2025
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Inventor(s): Christopher Walsh, Rachel Rodin, Michael Coulter, Peter Park, Craig Bohrson, Alison Barton, Minseok Kwon, Michael Lodato
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics
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Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains
Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease
Background
Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...
Published: 3/23/2026
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Updated: 4/3/2025
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Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Barcode for dementia: A molecular signature of Alzheimer’s disease and other tauopathies using mass spectrometry
Diagnostics of various Tauopathies
Background
Dementia and other cognitive disorders are serious medical issues that are of increasing concern as the global population ages. Dementia is not a specific disease, but rather a descriptive term for a collection of symptoms that can be caused by several disorders affecting the brain. People with...
Published: 3/24/2026
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Updated: 6/3/2024
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Inventor(s): Judith Steen, Hanno Steen, Jan Muntel
Keywords(s):
Category(s): Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Disease Area > Neurology
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Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease
Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease
Background
Alzheimer’s disease (AD) is the sixth-leading cause of death in the United States. It represents a major health challenge due to the following:
Population aging is associated with increased prevalence of dementia, with...
Published: 3/27/2026
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Updated: 7/17/2023
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Inventor(s): Hanno Steen, Patrick Van Zalm, Judith Steen
Keywords(s): CNS
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers
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Biomarkers of Neuropathic Pain
Biomarkers of Neuropathic Pain
They can be used to access neuropathic pain, diagnostics, clinical trials and in assessing therapeutic intervention for treating pain
Background
Pain is a sensory disturbance that is very difficult to measure accurately based on patients' subjective reports. There is an enormous need for objective and sensitive...
Published: 9/16/2025
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Updated: 2/15/2023
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Inventor(s): Clifford Woolf, Alban Latremoliere, Alexandre Chloe, Thomas Scammell
Keywords(s): Diagnostics, ZZCommon
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers
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Seizure Prediction Informed by Changes in Circadian Autonomic Modulation
Seizure Prediction Informed by Changes in Circadian Autonomic Modulation
An inexpensive, convenient, and non-invasive seizure detection, monitoring and prediction method
Background
Epilepsy affects 50 million people worldwide and it has highly debilitating medical and social consequences. Although the mechanism behind the seizures is believed to...
Published: 9/15/2025
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Updated: 2/14/2023
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Inventor(s): Solveig Vieluf, Bo Zhang, Tobias Loddenkemper
Keywords(s):
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers
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