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Targeting Gasdermin for Management of Inflammatory Diseases and Cancer
Targeting Gasdermin for Management of Inflammatory Diseases and Cancer
Background
Inflammation is a key factor in numerous diseases, including sepsis, inflammatory bowel disease, Alzheimer’s disease, and cancer. Millions worldwide are affected by these conditions, with sepsis affecting over 49 million people annually and Alzheimer’s impacting...
Published: 3/23/2026
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Updated: 3/9/2026
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area > Immunology > Inflammation, Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Method for Identifying Genomic Age via Single-Nucleotide Variants in Single Cell Neurons
Background
Aging in humans brings increased incidence of nearly all diseases, including neurodegeneration. Markers of DNA damage increase in the brain with age, and genetic progeroid diseases such as Cockayne syndrome (CS) and Xeroderma pigmentosum (XP), both...
Published: 3/23/2026
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Updated: 12/5/2025
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Inventor(s): Christopher Walsh, Rachel Rodin, Michael Coulter, Peter Park, Craig Bohrson, Alison Barton, Minseok Kwon, Michael Lodato
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics
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Enhancement of drug delivery across the blood-brain barrier for the treatment of brain diseases
Enhancement of drug delivery across the blood-brain barrier for the treatment of brain diseases
Background
The blood-brain barrier (BBB) is a critical structure that protects the brain and central nervous system (CNS) by preventing most substances from crossing into these areas from the bloodstream. This protective mechanism poses a significant challenge...
Published: 3/30/2026
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Updated: 10/6/2025
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Inventor(s): Marsha Moses, Golnaz Morad
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Identification and Treatment of Somatic Mutations in Mesial Temporal Lobe Epilepsy (MTLE)
Background
Epilepsy is a chronic neurological condition that affects over 50 million people worldwide. Mesial temporal lobe epilepsy (MTLE), the most common focal epilepsy, is characterized by recurrent focal seizures, memory issues, risk of injury due to recurrent...
Published: 3/23/2026
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Updated: 7/29/2025
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Inventor(s): Christopher Walsh, Kristopher Kahle, Sattar Khoshkhoo, Alice Lee, (Elain) Yilan Wang
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
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Compounds Treating AP-4 Associated Hereditary Spastic Paraplegia
Compounds Treating AP-4 Associated Hereditary Spastic Paraplegia
Background
Hereditary Spastic Paraplegia (HSP) is a group of inherited neurological disorders characterized by progressive spasticity, weakness, and gait abnormalities and affects approximately 5-10 per 100,000 individuals worldwide. Among its subtypes, Adaptor Protein Complex 4 (AP-4)-related...
Published: 3/23/2026
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Updated: 7/28/2025
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Inventor(s): Darius Ebrahimi-Fakhari, Mustafa Sahin, Masato Satoh, Jed Hubbs
Keywords(s): Hereditary Spastic Parapeligia, Movement Disorder, Neuromuscular Disorder
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Invention Type > Therapeutics > Small Molecule
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Microglia for scar-less healing, protection, and regeneration in the CNS
Microglia for scar-less healing, protection, and regeneration in the CNS
Background
Neuron injuries associated with neurodegenerative diseases, neuroinflammation, or physical spinal cord injury have very limited therapeutic options. These pathological conditions are often permanent and include cognitive decline, persistent physical pain, paralysis,...
Published: 10/6/2025
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Updated: 5/28/2025
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Inventor(s): Zhigang He, Yi Li, Xuelian He
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Therapeutics > Cell Therapy
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Methods to detect clonal somatic mutation from deep panel sequencing and bulk RNA-seq data and their application on identifying pathogenic role of somatic mutations in cell proliferation genes of Alzheimer brains
Methods for assessing neuroinflammation using somatic mutations in Alzheimer's Disease
Background
Alzheimer’s disease (AD) is a neurodegenerative condition that affects about 1 in 9 Americans aged 65 and older, with almost 7 million people currently affected and 14 million expected to be affected by 2060. One of the early pathogenic processes...
Published: 3/23/2026
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Updated: 4/3/2025
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Inventor(s): Christopher Walsh, Zinan Zhou, Alice Lee, (August) Yue Huang
Keywords(s): Neurodegeneration
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Disease Area > Neurology > Alzheimer's Disease
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Detection of epilepsy with analysis of electromagnetic signals (EEG)
Detection of epileptogenic brains with non-linear analysis of electromagnetic signals
Background
Epilepsy, one of the most prevalent chronic neurological diseases, affects approximately 0.6-1% of the general population and represents an economic burden of .1-1% of the total budget of health care systems in some parts of the world, with a significant...
Published: 3/30/2026
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Updated: 2/14/2025
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Inventor(s): William Bosl, Tobias Loddenkemper
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Neurology > Epilepsy, Technology Classifications > Invention Type > Diagnostics
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Bimanual Neuroendoscopic Robot for Minimally Invasive Brain Surgery
Bimanual Neuroendoscopic Robot for Minimally Invasive Brain Surgery
Background
Over 380,000 intracranial neurosurgical procedures are performed annually in the United States to treat brain tumors, trauma, epilepsy, hydrocephalus, and vascular lesions. The invasiveness of open microsurgery, used for the majority of cases, damages healthy brain...
Published: 12/5/2025
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Updated: 8/5/2024
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Inventor(s): Pierre Dupont, Karl Price
Keywords(s):
Category(s): Technology Classifications > Disease Area > Neurology, Technology Classifications > Disease Area > Surgery, Technology Classifications > Invention Type > Medical Devices
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Barcode for dementia: A molecular signature of Alzheimer’s disease and other tauopathies using mass spectrometry
Diagnostics of various Tauopathies
Background
Dementia and other cognitive disorders are serious medical issues that are of increasing concern as the global population ages. Dementia is not a specific disease, but rather a descriptive term for a collection of symptoms that can be caused by several disorders affecting the brain. People with...
Published: 3/24/2026
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Updated: 6/3/2024
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Inventor(s): Judith Steen, Hanno Steen, Jan Muntel
Keywords(s):
Category(s): Technology Classifications > Invention Type > Diagnostics, Technology Classifications > Invention Type > Biomarkers, Technology Classifications > Disease Area > Neurology
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