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TLR7/8 Ligands for Use in Opioid Vaccines
TLR7/8 Ligands for Use in Opioid Vaccines
Ligands with the potential for preventing fatal overdose of opioid users and protect against or treat Opioid Use Disorder patients
Technology Overview
Building on their work as part of the Precision Vaccines Program, researchers in the Levy lab have developed a method of enhancing immune response to anti-opioid...
Published: 3/24/2026
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Updated: 3/24/2026
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Inventor(s): Ofer Levy, David Dowling, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni
Keywords(s): Immunology, Therapeutic, ZZCommon, ZZTherapeutics:Vaccines
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Vaccines, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Intubation Shield - a foldable plastic shield that can be placed on the patient to protect the intubator and other healthcare workers in the room during intubation.
Intubation Shield: A foldable plastic shield to protect the patient and healthcare workers during intubation
Background
The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted global human health and is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This novel virus was first identified in China in...
Published: 3/27/2026
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Updated: 8/14/2023
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Inventor(s): Farokh Demehri, Heung Kim, Robert Crum, Brianna Slatnick, Kyle Wu, Alexander Yang, Pete Kovatsis, Nathaniel Tighe, Jonathan Durgin
Keywords(s): Medical Device, Respiratory
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Medical Devices, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Infectious Disease, Technology Classifications > Disease Area > Infectious Disease > COVID-19
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Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Enhancing Immunotherapy for Triple-Negative and HER2+ Breast Cancer Using EpCAM Aptamer-siRNAMediated Gene Knockdown
Background
Triple-negative (TNBC) and HER2+ breast cancers (BCs) are especially aggressive tumors with the worst prognosis as they are prone to relapse and metastasize post chemo- or targeted therapy. Immunotherapy provides...
Published: 3/9/2026
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Updated: 7/28/2023
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Inventor(s): Judy Lieberman, Ying Zhang
Keywords(s): Cancer, Oncology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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In situ targeted drug delivery to sites of intravascular heterotypic aggregates in sickle cell disease (SCD) by red blood cells encapsulated with drug candidates.
In situ targeted drug delivery to sites of intravascular heterotypic aggregates in sickle cell disease (SCD) by red blood cells encapsulated with drug candidates
Background
Recent advances highlight potential use of red blood cells (RBCs) as efficient drug delivery systems (DDS) for sickle cell disorders (SCD), either by incorporating the...
Published: 3/20/2026
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Updated: 7/17/2023
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Inventor(s): Leslie Silberstein, Shin-Young Park, Jina Ryu, Min Liu
Keywords(s): Immunology
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Rare Diseases, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery
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A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway
Background
Limited options exist for the effective treatment of Atopic dermatitis (AD), a common inflammatory condition affecting 20% of infants and children, due to a lack of understanding of specific treatment targets for AD. An improved genomic understanding of AD is needed...
Published: 9/16/2025
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Updated: 7/17/2023
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Inventor(s): Xi He, Maorong Chen, Nathalia Amado
Keywords(s): Common, Dermatology, Rheumatology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Small Molecule, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology
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Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease
Utilization of CerebroSpinal Fluid biomarkers for accurate identification of Alzheimer’s Disease
Background
Alzheimer’s disease (AD) is the sixth-leading cause of death in the United States. It represents a major health challenge due to the following:
Population aging is associated with increased prevalence of dementia, with...
Published: 3/27/2026
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Updated: 7/17/2023
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Inventor(s): Hanno Steen, Patrick Van Zalm, Judith Steen
Keywords(s): CNS
Category(s): Technology Classifications > Disease Area, Technology Classifications > Disease Area > Neurology, Technology Classifications > Invention Type, Technology Classifications > Invention Type > Biomarkers
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Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Mesenchymal Stromal Cell Exosomes for Thymic Dysfunction in Newborns
Background
Since the thymus is an essential organ for the production and maturation of specific immune T-cells, poor thymus development early in life can lead to multiple diseases related to immunological disorders. These diseases can manifest early, with an increased propensity...
Published: 3/23/2026
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Updated: 7/11/2023
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Inventor(s): Stella Kourembanas, S. Alex Mitsialis
Keywords(s): Immunology, Newborn Medicine
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Drug Delivery, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Autoimmune
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Novel Bacteriotherapies for the prevention and treatment of Food Allergy
Novel Bacteriotherapies for the prevention and treatment of Food Allergies
Background
Most food allergies are acquired in the first years of life, indicating a critical role for early childhood exposures in disease pathogenesis. Reduced bacterial diversity and an impaired ratio of specific bacteria in infancy have been associated with food sensitization,...
Published: 3/20/2026
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Updated: 7/11/2023
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Inventor(s): Talal Chatila, Azza Abdel-Gadir, Emmanuel Stephen Victor, Rima Rachid, Lynn Bry, Georg Gerber
Keywords(s): Allergy, Common, Food Allergy, Immunology
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Invention Type > Therapeutics > Microbiome, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Immunology > Allergy
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Synthetic genes that rewire natural immune pathways for anti-tumor defense
Synthetic genes that rewire natural immune pathways for anti-tumor defense
Background
Cancer is a malignant tumor resulting from the formation of abnormal cells in the body that can grow in an out-of-control fashion, eventually becoming fatal in the absence of effective, timely treatment. Interferons are a family of proteins that can naturally regulate...
Published: 3/9/2026
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Updated: 6/21/2023
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Inventor(s): Jonathan Kagan, Yunhao Tan
Keywords(s): Cancer, Oncology, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Novel Targets, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Oncology
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Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Development and evaluation of a truncated recombinant ADAMT13 micro-particle with extended release and enhanced protease plasmatic activity
Background
Blood coagulation is an essential physiological process where the blood changes from a liquid form into a thicker, gel-like form in response to a blood vessel injury thereby preventing excessive blood...
Published: 6/26/2025
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Updated: 6/21/2023
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Inventor(s): Daniel Kohane, Juan Ibla, Upendra Katneni, Chava Kimchi-Sarfaty
Keywords(s): Cardiovascular, Molecules/ Proteins, Therapeutic
Category(s): Technology Classifications > Invention Type, Technology Classifications > Invention Type > Therapeutics, Technology Classifications > Disease Area, Technology Classifications > Disease Area > Hematology, Technology Classifications > Invention Type > Therapeutics > Protein
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